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Yi Qukang Zun and the toenail fungus that compare naphthalene fragrance to treat

From;    Author:Stand originally
Aditya K.Gupta, MD, FRCPC, nellie Konnilov, MD, and Charles W.Lynde, MD, FRCPC, toronto, ontario, canada, and Boston, massachusetts


Summary

Setting: Of the toenail fungus disease that causes to skin tinea bacterium the commonnest medication the method is: Therapeutics of concussion of Yi Qukang Zun and compare naphthalene fragrance successive therapeutics especially. Although already had an opinion,these two kinds of medicaments are opposite the research of adult patient curative effect, but the research that is aimed at senile patient has not appeared in the newspaper.

Purpose: This research is before random sheet blind has look up sex those who contrast, be not the clinical trial that manufacturer funds, evaluation of in order to, therapeutics of concussion of Yi Qukang Zun and compare naphthalene fragrance successive therapeutics especially, the curative effect of the toenail fungus disease that treats bacterium of tinea of senile patient skin to cause and security.

Method: The senile patient of the disease of fungus of armour of sex of skin tinea bacterium that will have be put into trouble of toenail of foot of a Mu at least (≥ 60 years old) random cent is two groups, zun of a group of Qu Kang that it is Yi (pound) cure, 200 m g is daily 2, week of the 1 that take drug pounds cure for, undertake 3 percussive are treated in all; Another group is accepted compare naphthalene fragrance especially d of / of 250 m g in all 12 weeks cure. Beginning the 6th month after cure, if be compared with the photograph when first visit to a doctor, of area of board of patient be put into trouble decrease be less than 50 % , or measure place to be with central line place accurate, board not the length of area of be put into trouble is less than 3 m m , so accept compare naphthalene fragrance especially (successive) remedial patient reassume 4 weeks compare naphthalene fragrance to treat especially (in all 16 weeks cure) ; And Zun of those the Qu Kang that use Yi (concussion) remedial patient will be added take a percussive Yi Qukang Zun is treated (the 4th concussion) . The 1 after begins in cure. 5, 3, 6, 12 and undertake assessment to the patient when 18 months. The index that evaluates curative effect includes: Cleared rate mixes true mycology clinical businesslike (true mycology treats all the more to go up clinical cure or improve, because this remnant has 10 % or fewer board be put into trouble) .

Result: Share 101 senile patient to enter this group of research, among them 51 accept Yi Qukang Zun, 50 are accepted compare naphthalene fragrance to treat especially. Group of Yi Qukang Zun includes 24 males patient and 27 female patient, the age is (all be worth ± standard deviation) 68. 8 ± 0. 8 years old, armour fungus ill course of diseases is (all be worth ± standard deviation) 16. 1 ± 1 . 7 years, the amount of armour of be put into trouble is (all be worth ± standard deviation) 6. 0 ± 0. 7, the per cent of area of board be put into trouble is (all be worth ± standard deviation) 74. 9 % ± 3. 8 % . Compare naphthalene fragrance group to include 28 males patient and 22 females patient especially, the age is (all be worth ± standard deviation) 68. 0 ± 0. 9 years old, armour fungus ill course of diseases is (all be worth ± standard deviation) 18. 2 ± 1 . 4 years, the amount of armour of be put into trouble is (all be worth ± standard deviation) 5. 5 ± 0. 5, the per cent of area of be put into trouble of the board when first visit to a doctor is (all be worth ± standard deviation) 67. 5 % ± 4. 2 % . Above data treats across block nonsignificant difference in two. When the 6th month, medication in propylene amine group need adds the patient number that takes 4 week spy to compare naphthalene fragrance to be 13 / 50, 3 Zun kind medication 51 need to add the patient that pounds cure with Yi Qukang Zun to be 23 / in the group. When the 18th month, compare fungus of naphthalene fragrance group to learn to keep clear of especially lead and clinical businesslike it is respectively 64. 0 % and 62. 0 % , yi Qukang Zun (concussion) constituent is 62. 7 % and 60. 8 % , nonsignificant difference of two across block. The patient that midway exits is not had in cure. Two treatment group indicated the security of medicaments, happen without remarkable undesirable incident and remarkable lab is unusual expression. All undesirable incident are slight and brief.
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